Calcium acetate

Pharmacologic Category

•         Antidote
•         Calcium salt
•         Phosphate Binder

Dosing: Adult

Control of Serum phosphorus: Chronic Kidney Disease:

 Oral: Initially, 1334 mg with each meal is administered. This can be moderately increased (every 2 to 3 weeks) to bring the serum phosphate to the chosen range as long as hypercalcemia does not emerge. Here the usual dosage recommended is 2001 to 2668 mg calcium acetate along with each meal. No additional calcium acetate supplements are to be administered.

Dietary supplement (OTC): 1 to 3 tablets are to be consumed with meal thrice a day

Dosing: Renal Impairment: Adult:

No adjustment of dose is required

Dosing: Hepatic Impairment: Adult:

No adjustment of dose is provided in the manufacturer’s labelling.

Administration: Adult

Oral: The dose is to be taken along with the meals

Adverse reactions:

The following adverse drug responses and appearances are derived from the product labelling unless otherwise mentioned:

≥10%:

Endocrine & metabolic: Hypercalcemia

Gastrointestinal : Diarrhea (oral solution)

Contradictions

Hypercalcemia

Warnings and Precautions

Concerns about unfavorable effects:

•         Gastrointestinal effects
•         Hypercalcemia

Dietary considerations

Oral dosage forms must be consumed with meals to be fruitful

Mechanism of Action

It blends with dietary phosphate to form insoluble calcium phosphate, which is discharged in stools.

Pharmacodynamics and Pharmacokinetics

•         Absorption: 30% to 40%
•         Requires Vitamin D otherwise persistent high doses of calcium acetate are given
•         Calcium is absorbed in the solution, Ionized form
•         In an acid environment, solubility of the calcium is increased

Indian brands

•         Fosbind
•         Septacal
•         Phostat
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